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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
22.42
Human Site:
T532
Identified Species:
35.24
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
T532
G
E
A
E
G
A
E
T
T
K
R
P
A
V
C
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
T532
G
E
A
E
G
A
E
T
T
K
R
P
A
V
C
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
T532
G
E
A
E
G
A
E
T
T
K
R
L
A
V
C
Dog
Lupus familis
XP_543464
544
61233
T533
G
E
A
E
D
A
D
T
T
K
R
L
A
M
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
S535
L
E
V
E
G
M
P
S
T
K
R
L
S
V
C
Rat
Rattus norvegicus
NP_446129
545
60912
S534
L
E
A
E
D
A
E
S
S
K
R
L
A
V
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
T515
E
E
E
E
Q
P
G
T
S
K
C
S
V
P
C
Chicken
Gallus gallus
NP_001073576
522
58779
S509
N
E
D
E
S
V
S
S
K
R
D
V
P
S
T
Frog
Xenopus laevis
NP_001082016
517
58243
C503
Q
D
A
S
T
S
S
C
S
E
I
L
P
T
S
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
R414
K
E
L
R
E
L
N
R
R
Y
Q
Q
Q
C
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
E468
I
E
E
E
N
F
L
E
P
P
T
K
R
S
R
Honey Bee
Apis mellifera
XP_624334
480
54300
L472
K
N
E
Q
Y
H
N
L
I
K
R
A
R
L
E
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
A468
A
A
L
Q
T
T
Q
A
G
P
V
K
K
A
K
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
A471
S
K
V
V
A
K
V
A
A
K
V
A
A
G
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
I503
L
Q
I
T
D
N
K
I
P
K
T
Y
S
E
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
93.3
73.3
N.A.
53.3
66.6
N.A.
33.3
13.3
6.6
6.6
N.A.
13.3
13.3
0
13.3
P-Site Similarity:
100
100
93.3
86.6
N.A.
66.6
80
N.A.
40
26.6
33.3
13.3
N.A.
13.3
26.6
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
40
0
7
34
0
14
7
0
0
14
40
7
0
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
7
0
0
7
47
% C
% Asp:
0
7
7
0
20
0
7
0
0
0
7
0
0
0
0
% D
% Glu:
7
67
20
60
7
0
27
7
0
7
0
0
0
7
7
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
27
0
0
0
27
0
7
0
7
0
0
0
0
7
7
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
7
0
0
0
0
7
7
0
7
0
0
0
0
% I
% Lys:
14
7
0
0
0
7
7
0
7
67
0
14
7
0
7
% K
% Leu:
20
0
14
0
0
7
7
7
0
0
0
34
0
7
7
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
0
7
0
% M
% Asn:
7
7
0
0
7
7
14
0
0
0
0
0
0
0
7
% N
% Pro:
0
0
0
0
0
7
7
0
14
14
0
14
14
7
0
% P
% Gln:
7
7
0
14
7
0
7
0
0
0
7
7
7
0
0
% Q
% Arg:
0
0
0
7
0
0
0
7
7
7
47
0
14
0
7
% R
% Ser:
7
0
0
7
7
7
14
20
20
0
0
7
14
14
7
% S
% Thr:
0
0
0
7
14
7
0
34
34
0
14
0
0
7
7
% T
% Val:
0
0
14
7
0
7
7
0
0
0
14
7
7
34
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
7
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _